abstract：:The Hepatitis B virus (HBV) e antigen (HBeAg) is a secretory, non-structural protein, and associated with persistent infection of HBV. Previous studies indicate that HBeAg is able to regulate T cell-mediated responses, however, the interaction between HBeAg and the innate immune system is poorly understood. In this st...

journal_title：Immunobiology

authors： Leu CM,Lu YC,Peng WL,Chu HT,Hu CP

更新日期：2014-11-01 00:00:00

abstract：:α-Synuclein plays a crucial role in Parkinson's disease and dementias defined as synucleinopathies. α-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown. We utilized α-synuclein(-/-) (KO) mice to investigate its role in hematopoiesis and B cell...

journal_title：Immunobiology

authors： Xiao W,Shameli A,Harding CV,Meyerson HJ,Maitta RW

更新日期：2014-11-01 00:00:00

abstract：:Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activat...

journal_title：Immunobiology

authors： Nymo S,Niyonzima N,Espevik T,Mollnes TE

更新日期：2014-10-01 00:00:00

abstract：:Integration of cellular and humoral arms of the innate immune response is fundamental to the development of powerful effector functions in host defence as well as aberrant immune responses. Here, we provide evidence in support of the relationship between complement activation and NK cell functional modulation. We demo...

journal_title：Immunobiology

authors： Min X,Liu C,Wei Y,Wang N,Yuan G,Liu D,Li Z,Zhou W,Li K

更新日期：2014-09-01 00:00:00

abstract：:Cytokines play critical roles in the pathogenesis of Behçet's disease (BD). They mediated many of the effectors and regulatory functions of immune and inflammatory responses. Many studies have linked Interleukin-6 (IL-6) and Interleukin-10 (IL-10) pathologically to BD. Thus, this study aimed to investigate the associa...

journal_title：Immunobiology

authors： Talaat RM,Ashour ME,Bassyouni IH,Raouf AA

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Analysis of peripheral blood lymphocyte subsets has become an essential tool in the evaluation of outcome of diagnostic and research related questions in immunological and pathological conditions. Periodic evaluation and establishment of normal lymphocyte reference ranges are required in clinical and researc...

journal_title：Immunobiology

authors： Valiathan R,Deeb K,Diamante M,Ashman M,Sachdeva N,Asthana D

更新日期：2014-07-01 00:00:00

abstract：:The mechanisms that mediate accelerated atherosclerosis in autoimmune diseases remain unclear. One common mechanism that has been documented in autoimmune diseases and atherosclerosis is formation of hypoglycosyalted N-glycans on the cell surface. In this study we tested the effects of swainsonine, a class II α-mannos...

journal_title：Immunobiology

authors： Scott DW,Black LL,Vallejo MO,Kabarowski JH,Patel RP

更新日期：2014-07-01 00:00:00

abstract：:Germinal centers are the anatomic sites for the generation of high affinity immunoglobulin expressing plasma cells and memory B cells. The germinal center B cells that are precursors of these cells circulate between the light zone B cell population that interact with antigen laden follicular dendritic cells (FDC) and ...

journal_title：Immunobiology

authors： Donius LR,Weis JJ,Weis JH

更新日期：2014-06-01 00:00:00

abstract：:Dengue fever, a public health problem in Brazil, may present severe clinical manifestations as result of an increased vascular permeability and coagulation disorders. T cell activation is a critical event for an effective immune response against infection, including the production of cytokines. We aim to reveal mechan...

journal_title：Immunobiology

authors： Torrentes-Carvalho A,Marinho CF,de Oliveira-Pinto LM,de Oliveira DB,Damasco PV,Cunha RV,de Souza LJ,de Azeredo EL,Kubelka CF

更新日期：2014-05-01 00:00:00

abstract：:T-lymphocytes, including Th17-cells and T-cells expressing acetylcholine (ACh), are key components of systemic inflammation in chronic obstructive pulmonary disease (COPD). We investigated whether ACh promotes Th17 cells in COPD. ACh, IL-17A, IL-22, RORγt, FOXP3 expression and AChIL-17A, AChIL-22, AChRORγt coexpressio...

journal_title：Immunobiology

authors： Profita M,Albano GD,Riccobono L,Di Sano C,Montalbano AM,Gagliardo R,Anzalone G,Bonanno A,Pieper MP,Gjomarkaj M

更新日期：2014-05-01 00:00:00

abstract：:Shigella spp. are known to penetrate the colonic epithelial cells causing shigellosis, which results in production of convalescent antibodies against porin, the surface exposed major outer membrane protein. Porin has been categorized as primarily TLR2-ligand and here we validated its signaling procedure in colonic INT...

journal_title：Immunobiology

authors： Mukherjee S,Sinha D,Ghosh AK,Biswas T

更新日期：2014-05-01 00:00:00

abstract：:Memory T cells producing interferon (IFN)γ and expressing very late antigen-1 (VLA-1) integrin collagen receptors are found in carotid atherosclerotic plaques, suggesting their involvement in coronary artery disease (CAD) as well. To determine the role of VLA-1+ T cells in CAD percent of CD3+ T cells binding monoclona...

journal_title：Immunobiology

authors： Asman A,Chouraqui P,Marcu-Malina V,Matetzky S,Segev A,Fefer P,Agranat O,Koltakov A,Hod H,Livneh A,Bank I

更新日期：2014-04-01 00:00:00

abstract：:This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (-/-) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP-/- mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inflammation was restr...

journal_title：Immunobiology

authors： Ge L,Trujillo G,Miller EJ,Kew RR

更新日期：2014-03-01 00:00:00

abstract：:Chitin and β-glucan are conserved throughout evolution in the fungal cell wall and are the most common polysaccharides in fungal species. Together, these two polysaccharides form a structural scaffold that is essential for the survival of the fungus. In the present study, we demonstrated that Aspergillus fumigatus alk...

journal_title：Immunobiology

authors： Dubey LK,Moeller JB,Schlosser A,Sorensen GL,Holmskov U

更新日期：2014-03-01 00:00:00

abstract：PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...

journal_title：Immunobiology

authors： Dons'koi BV,Chernyshov VP,Sirenko VY,Strelko GV,Osypchuk DV

更新日期：2014-03-01 00:00:00

abstract：:Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins. These enzymes are best known for their roles in modulating the activity of kinins, complement anaphylatoxins and coa...

journal_title：Immunobiology

authors： Hu X,Wetsel RA,Ramos TN,Mueller-Ortiz SL,Schoeb TR,Barnum SR

更新日期：2014-02-01 00:00:00

abstract：:The enhancing effects of the complement system for humoral immunity have primarily focused upon the recognition of complement-bound foreign antigens by a co-receptor complex of the antigen-specific B cell receptor (BCR) and complement receptor 2 (Cr2). In vivo experiments using Cr2 gene deficient mice (which lack the ...

journal_title：Immunobiology

authors： Donius LR,Orlando CM,Weis JJ,Weis JH

更新日期：2014-01-01 00:00:00

abstract：:The defective antigen presenting ability of antigen presenting cells (APCs) modulates host cytokines and co-stimulatory signals that may lead to severity of leprosy. In the present study, we sought to evaluate the phenotypic features of APCs along with whether DC SIGN (DC-specific intercellular adhesion molecule-grabb...

journal_title：Immunobiology

authors： Kumar S,Naqvi RA,Bhat AA,Rani R,Ali R,Agnihotri A,Khanna N,Rao DN

更新日期：2013-12-01 00:00:00

abstract：:CD4(+)CD25(+)Foxp3(+) T regulatory cells (Tregs) and CD1d-restricted invariant natural killer T (iNKT) cells are two cell types that are known to regulate immune reactions. Depletion or inactivation of Tregs using specific anti-CD25 antibodies in combination with immunostimulation is an attractive modality especially ...

journal_title：Immunobiology

authors： Rosalia RA,Štěpánek I,Polláková V,Šímová J,Bieblová J,Indrová M,Moravcová S,Přibylová H,Bontkes HJ,Bubeník J,Sparwasser T,Reiniš M

更新日期：2013-06-01 00:00:00

abstract：:To recognize patients with inhibitory and neutralizing auto-antibodies to interferon-γ (AutoAbs-IFN-γ) presenting with the sporadic phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) mainly characterized by recurrent intracellular mycobacterium or/and salmonella infections, we comprehensively invest...

journal_title：Immunobiology

authors： Lee WI,Huang JL,Wu TS,Lee MH,Chen IJ,Yu KH,Liu CY,Yang CH,Hsieh MY,Lin YL,Shih YF,Jaing TH,Huang SC,Kuo TT,Ku CL

更新日期：2013-05-01 00:00:00

abstract：:To differentiate severe congenital neutropenia (SCN) from autoimmune neutropenia (AIN) in patients with persistent neutropenia ≤1000/mm(3) over three months, we evaluated anti-neutrophil auto-antibodies, candidate genes of ELANA, HAX1 and GCSFR, and neutrophil elastase (NE) activity in 38 patients (21 females; average...

journal_title：Immunobiology

authors： Lee WI,Chen SH,Huang JL,Jaing TH,Chung HT,Yeh KW,Chen LC,Yao TC,Hsieh MY,Lin SJ,Kuo ML

更新日期：2013-05-01 00:00:00

abstract：:B-1 cells can be differentiated from B-2 cells because they are predominantly located in the peritoneal and pleural cavities and have distinct phenotypic patterns and activation properties. The role of both cell populations in cancer progression is still controversial. Previous studies have indicated that direct conta...

journal_title：Immunobiology

authors： Laurindo MF,Thies FG,Perez EC,Novaes e Brito RR,Mariano M,Popi AF

更新日期：2013-04-01 00:00:00

abstract：:Cryptococcus neoformans is a pathogenic fungus causing life threatening infections in humans. The present in vitro study aimed to investigate the opsonizing properties of a well characterized serum ficolin (rat ficolin-A), a member of carbohydrate-recognition molecules of the innate immune system, in the defence again...

journal_title：Immunobiology

authors： Schelenz S,Kirchhof N,Bidula S,Wallis R,Sexton DW

更新日期：2013-04-01 00:00:00

abstract：:This study tested the hypothesis that CD4(+)CD25(+)CD127(low) regulatory T (Treg) cells might induce immunosuppressive properties in apoptotic neutrophils. Treg cells are recognized as a major subset of immune cells possessing potent suppressive properties directed at T effector cells. However, Treg cells have recentl...

journal_title：Immunobiology

authors： Lewkowicz N,Klink M,Mycko MP,Lewkowicz P

更新日期：2013-04-01 00:00:00

abstract：:Alternative macrophage activation is largely defined by IL-4Rα stimulation but the contribution of Toll-like receptor (TLR) signaling to this phenotype is not currently known. We have investigated macrophage activation status under Th2 conditions in the absence of the core TLR adaptor molecule, MyD88. No impairment wa...

journal_title：Immunobiology

authors： Mylonas KJ,Hoeve MA,MacDonald AS,Allen JE

更新日期：2013-04-01 00:00:00

abstract：:Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, induces pro-inflammatory responses including early T helper (Th)1 differentiation and generation of cytotoxic T lymphocytes, and also anti-inflammatory responses including the differentiation to IL-10-producing regulatory T cells, inhibitio...

journal_title：Immunobiology

authors： Shimizu M,Ogura K,Mizoguchi I,Chiba Y,Higuchi K,Ohtsuka H,Mizuguchi J,Yoshimoto T

更新日期：2013-04-01 00:00:00

abstract：:In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to S...

journal_title：Immunobiology

authors： Trück J,Lazarus R,Clutterbuck EA,Bowman J,Kibwana E,Bateman EA,Pollard AJ

更新日期：2013-03-01 00:00:00

abstract：:Dendritic cells (DCs) are potent antigen-presenting cells that initiate the primary immune response and whose functional properties in vivo depend on the maturation stimulus. We describe the functional properties of human monocyte-derived DCs after the maturation of immature DCs (iDCs) for 2 days with LPS (100 ng/ml),...

journal_title：Immunobiology

authors： da Silva I,Gomes GG,Menezes CC,Palma PV,Orellana MD,Covas DT,Chammas R,Greene LJ

更新日期：2013-02-01 00:00:00

abstract：:Toll-like receptors (TLR) initiate innate and often affect adaptive immune response. This study aimed to determine if TLR response and T regulatory cell (Treg) function in peripheral blood mononuclear cells (PBMC) correlate with clinical severity in non-infectious asthma. TLR1-9 expression and representative response ...

journal_title：Immunobiology

authors： Lee WI,Yao TC,Yeh KW,Chen LC,Ou LS,Huang JL,PATCH Study Group.

更新日期：2013-02-01 00:00:00

abstract：:In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral tissue antigen (PTA) gene, which is Aire-dependent, is...

journal_title：Immunobiology

authors： Oliveira EH,Macedo C,Donate PB,Almeida RS,Pezzi N,Nguyen C,Rossi MA,Sakamoto-Hojo ET,Donadi EA,Passos GA

更新日期：2013-01-01 00:00:00

abstract：:Macrophage pre-treatment with bacterial lipopolysaccharide (LPS) boosts subsequent activation of the NLRP3 inflammasome, which controls caspase-1-dependent pro-inflammatory cytokine maturation. Previous work has attributed this phenomenon (known as LPS 'priming') to LPS-dependent induction of NLRP3 expression. Whilst ...

journal_title：Immunobiology

authors： Schroder K,Sagulenko V,Zamoshnikova A,Richards AA,Cridland JA,Irvine KM,Stacey KJ,Sweet MJ

更新日期：2012-12-01 00:00:00

abstract：:Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effec...

journal_title：Immunobiology

authors： Worthington JJ,Fenton TM,Czajkowska BI,Klementowicz JE,Travis MA

更新日期：2012-12-01 00:00:00

abstract：:The vitamin D receptor (VDR) is a hormone nuclear receptor regulating bone and calcium homeostasis. Studies revealing the expression of VDR on immune cells point toward a role for VDR-dependent signaling pathways in immunity. Here we verified the ability of the natural VDR ligand, 1,25-dihydroxyvitamin D(3) (1,25(OH)(...

journal_title：Immunobiology

authors： Korf H,Wenes M,Stijlemans B,Takiishi T,Robert S,Miani M,Eizirik DL,Gysemans C,Mathieu C

更新日期：2012-12-01 00:00:00

abstract：:Attenuating the sepsis-induced systemic inflammatory response, with subsequent homeostatic imbalance, has for years been one of the main tasks in sepsis related research. Complement and the TLR family constitute two important upstream sensor and effector-systems of innate immunity. Although they act as partly independ...

journal_title：Immunobiology

authors： Barratt-Due A,Pischke SE,Brekke OL,Thorgersen EB,Nielsen EW,Espevik T,Huber-Lang M,Mollnes TE

更新日期：2012-11-01 00:00:00

abstract：:Ficolins and mannan-binding lectin recognize pathogen-associated molecular patterns and initiate the lectin pathway of complement activation via the associated serine proteases. In contrast to human ficolins and mouse ficolin-A, mouse ficolin-B has been considered incapable of complement activation. Dose-dependent bin...

journal_title：Immunobiology

authors： Hunold K,Weber-Steffens D,Runza VL,Jensenius JC,Männel DN

更新日期：2012-10-01 00:00:00

abstract：:The expansion of effector T cells is tightly controlled by transcription factors like nuclear factor of activated T cells (NFAT) family members that mediate early intracellular responses to T cell receptor-mediated signals. In this study we show that, after allergen challenge, NFATc2((-/-)) mice had augmented number o...

journal_title：Immunobiology

authors： Karwot R,Übel C,Bopp T,Schmitt E,Finotto S

更新日期：2012-09-01 00:00:00

abstract：:The collectins are a group of innate immune proteins structurally characterized by their content of a carbohydrate recognition domain and a collagen-like region. Collectin liver 1 (CL-L1) and collectin 11 (CL-11, alias collectin kidney 1, CL-K1) are the more recently described members of this group. Their genomic orga...

journal_title：Immunobiology

authors： Selman L,Hansen S

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infi...

journal_title：Immunobiology

authors： Jarazo-Dietrich S,Jacobo P,Pérez CV,Guazzone VA,Lustig L,Theas MS

更新日期：2012-08-01 00:00:00

abstract：:All-trans retinoic acid (ATRA) is a potent retinoid, which has been used successfully in different clinical settings as a potential drug to treat COPD and emphysema. In the present study, we analyzed genes modulated by ATRA by performing mRNA expression array analysis on alveolar macrophages after treatment with ATRA....

journal_title：Immunobiology

authors： Mamidi S,Hofer TP,Hoffmann R,Ziegler-Heitbrock L,Frankenberger M

更新日期：2012-06-01 00:00:00

abstract：:Intestinal epithelial cells produce cytokines in response to bacterial peptidoglycan (PGN), which is detected by several classes of pattern-recognition receptors (PRRs) as peptidoglycan recognition proteins (PGlyRPs), Toll-like receptor 2 (TLR2) and NOD receptors. All types of PGlyRPs recognize bacterial peptidoglycan...

journal_title：Immunobiology

authors： Zenhom M,Hyder A,de Vrese M,Heller KJ,Roeder T,Schrezenmeir J

更新日期：2012-04-01 00:00:00